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Completely updated and reorganized, Principles of Neural Science, Fourth Edition provides an authoritative introduction to the brain: its structure, function, development, and control of behavior. The textbook presents an in-depth summary of the state of the science as well as a full discussion of historical issues. Neuroanatomy, cell and molecular mechanisms of signaling, development and plasticity are thoroughly described in the context of cognitive approaches to behavior.

Table of contents

	Contents	ix
	Preface	xxxv
	Acknowledgments	xxxvii
	Contributors	xxxix
Part I	The Neurobiology of Behavior
1	The Brain and Behavior	5
2	Nerve Cells and Behavior	19
3	Genes and Behavior	36
Part II	Cell and Molecular Biology of the Neuron
4	The Cytology of Neurons	67
5	Synthesis and Trafficking of Neuronal Protein	88
6	Ion Channels	105
7	Membrane Potential	125
8	Local Signaling: Passive Electrical Properties of the Neuron	140
9	Propagated Signaling: The Action Potential	150
Part III	Elementary Interactions Between Neurons: Synaptic Transmission
10	Overview of Synaptic Transmission	175
11	Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission	187
12	Synaptic Integration	207
13	Modulation of Synaptic Transmission: Second Messengers	229
14	Transmitter Release	253
15	Neurotransmitters	280
16	Diseases of Chemical Transmission at the Nerve-Muscle Synapse: Myasthenia Gravis	298
Part IV	The Neural Basis of Cognition
17	The Anatomical Organization of the Central Nervous System	317
18	The Functional Organization of Perception and Movement	337
19	Integration of Sensory and Motor Function: The Association Areas of the Cerebral Cortex and the Cognitive Capabilities of the Brain	349
20	From Nerve Cells to Cognition: The Internal Cellular Representation Required for Perception and Action	381
Part V	Perception
21	Coding of Sensory Information	411
22	The Bodily Senses	430
23	Touch	451
24	The Perception of Pain	472
25	Constructing the Visual Image	492
26	Visual Processing by the Retina	507
27	Central Visual Pathways	523
28	Perception of Motion, Depth, and Form	548
29	Color Vision	572
30	Hearing	590
31	Sensory Transduction in the Ear	614
32	Smell and Taste: The Chemical Senses	625
Part VI	Movement
33	The Organization of Movement	653
34	The Motor Unit and Muscle Action	674
35	Diseases of the Motor Unit	695
36	Spinal Reflexes	713
37	Locomotion	737
38	Voluntary Movement	756
39	The Control of Gaze	782
40	The Vestibular System	801
41	Posture	816
42	The Cerebellum	832
43	The Basal Ganglia	853
Part VII	Arousal, Emotion, and Behavior Homeostasis
44	Brain Stem, Reflexive Behavior, and the Cranial Nerves	873
45	Brain Stem Modulation of Sensation, Movement, and Consciousness	889
46	Seizures and Epilepsy	910
47	Sleep and Dreaming	936
48	Disorders of Sleep and Wakefulness	948
49	The Autonomic Nervous System and the Hypothalamus	960
50	Emotional States and Feelings	982
51	Motivational and Addictive States	998
Part VIII	The Development of the Nervous System
52	The Induction and Patterning of the Nervous System	1019
53	The Generation and Survival of Nerve Cells	1041
54	The Guidance of Axons to Their Targets	1063
55	The Formation and Regeneration of Synapses	1087
56	Sensory Experience and the Fine-Tuning of Synaptic Connections	1115
57	Sexual Differentiation of the Nervous System	1131
58	Aging of the Brain and Dementia of the Alzheimer Type	1149
Part IX	Language, Thought, Mood, and Learning, and Memory
59	Language and the Aphasias	1169
60	Disorders of Thought and Volition: Schizophrenia	1188
61	Disorders of Mood: Depression, Mania, and Anxiety Disorders	1209
62	Learning and Memory	1227
63	Cellular Mechanisms of Learning and the Biological Basis of Individuality	1247
	Appendices
A	Current Flow in Neurons	1280
B	Ventricular Organization of Cerebrospinal Fluid: Blood-Brain Barrier, Brain Edema, and Hydrocephalus	1288
C	Circulation of the Brain	1302
D	Consciousness and the Neurobiology of the Twenty-First Century	1317
	Index	1321